Topical treatment clears precancerous skin lesions

first_img First demonstration of a melanoma arising from a single cell Calcipotriol, an FDA-approved treatment for psoriasis, induces expression in the skin of an immune-system activator called TSLP. While overexpression of TSLP is associated with the allergic inflammation seen in asthma and eczema, it has been noted that individuals with these allergic conditions appear to be less susceptible to skin cancer. Other studies have supported TSLP’s ability to suppress skin cancer development, which led Demehri’s team to investigate its potential against actinic keratosis.Experiments with a mouse model of skin cancer development showed that twice-weekly applications of calcipotriol both induced TSLP expression and delayed tumor development. When tumors did develop, they were fewer and smaller than in mice not treated with calcipotriol. An experiment in which calcipotriol was applied to the ears of mice while skin cancer was induced to develop on their backs resulted in elevated blood levels of TSLP and the suppression of tumor development, implying that brief TSLP-inducing treatment could lead to a lasting systemic antitumor immune response.Since clinically available concentrations of calcipotriol have had limited effectiveness against actinic keratosis and produced no evidence of immune activation, the MGH team hypothesized that combining the available 0.005 percent calcipotriol ointment with 5 percent fluorouracil (5-FU) cream, a standard treatment for actinic keratosis, might amplify the immune-activating potential of calcipotriol. In a randomized, double-blinded clinical trial, 65 participants with multiple actinic keratosis lesions were treated with a combination of calcipotriol and 5-FU, while 67 received a control preparation of 5-FU mixed with petroleum jelly.The preparations were applied twice a day to the entire affected sites of participants — face, scalp, and arms — and because treatment with 5-FU alone requires seven or more days to have any effect against actinic keratosis, participants were treated for four days only. A day after treatment ended, the treated skin of those receiving calcipotriol plus 5-FU, including areas that did not contain clinically visible lesions, showed clear signs of inflammation, indicating immune system activation. Areas of inflammation were found to have a significant influx of lymphocytes — primarily T cells — at the sites of lesions.Eight weeks after treatment, participants receiving the combined treatment had a significantly greater reduction in the number and size of actinic keratosis lesions — for example, an average of 88 percent reduction in facial lesions versus 26 percent reduction for those receiving the control preparation. Even participants with large “hypertrophic” lesions, which rarely respond to conventional topical treatments, saw significant reduction in the size of their lesions with combined treatment. Among participants receiving combined treatment who previously had been treated for actinic keratosis, 82 percent found the treatment more effective.“As both medications used in our trial are already available clinically, they could readily be used by dermatologists to treat actinic keratosis, particularly in patients for whom conventional treatments have failed,” says Demehri, who is an assistant professor of dermatology at Harvard Medical School. “The ultimate goal of our research is to use patients’ own immune systems to prevent cancer, so we are very excited to determine whether our success in activating a T-cell-dominant immune response against a skin cancer precursor will protect the treated skin against future skin cancer development. We’re planning to follow the participants in this trial over the coming years to address that important question.”Trevor Cunningham of the MGH Center for Cancer Immunology and CBRC is lead author of the Journal of Clinical Investigation report.The study was supported by National Institutes of Health grants and grants from the American Skin Association, the Dermatology Foundation, the Burroughs Wellcome Fund, the American Philosophical Society, and the La Roche-Posay Research Foundation. MGH has filed a patent application covering the work described in this paper. A cancer’s surprise origins, caught in action Related A combination of two FDA-approved drugs — a topical chemotherapy and an immune system-activating compound — was able to rapidly clear actinic keratosis lesions from patients participating in a clinical trial. Standard treatment for this common skin condition, which can lead to the development of squamous cell carcinoma, takes up to a month and can elicit several unpleasant side effects. The report from Harvard-affiliated Massachusetts General Hospital (MGH) investigators has been published online and will appear in the January issue of the Journal of Clinical Investigation.“The high tumor-clearance rate, short treatment duration, and favorable side-effect profile highlight the remarkable effectiveness of this approach, compared with currently available treatments,” says Shadmehr Demehri of the MGH Center for Cancer Immunology and the Cutaneous Biology Research Center (CBRC), senior author of the report. “But more importantly, the unprecedented ability of this combination therapy to directly activate the adaptive immune system against skin cancer precursors holds great promise to establish an immune memory within treated skin capable of preventing future cancer development.”Caused by long-term exposure to sunlight, actinic keratosis is characterized by rough, scaly patches on the skin. Very common in older individuals with fair complexions, actinic keratosis is the third-most-common reason for consulting a dermatologist in the U.S. If untreated, actinic keratosis lesions can progress to squamous cell carcinoma, the second-most-common form of skin cancer. Current topical treatments for actinic keratosis cause side effects — such as pain, crusting, and susceptibility to infection — and need to be applied for up to four weeks.last_img read more

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For new medicines, turn to pioneers

first_imgWould we be wise to prioritize “shovel-ready” science over curiosity-driven, fundamental research programs? In the long term, would that set the stage for the discovery of more medicines?To find solid answers to these questions, scientists at Harvard and the Novartis Institute for Biomedical Research (NIBR), publishing in Science Translational Medicine, looked deep into the discovery of drugs and showed that, in fact, fundamental research is “the best route to the generation of powerful new medicines.”“The discoveries that lead to the creation of a new medicine do not usually originate in an experiment that sets out to make a drug. Rather, they have their origins in a study — or many studies — that seek to understand a biological or chemical process,” said Mark Fishman, one of three authors of the study. “And often many years pass, and much scientific evidence accumulates, before someone realizes that maybe this work holds relevance to a medical therapy. Only in hindsight does it seem obvious.”Fishman is a professor in the Harvard Department of Stem Cell and Regenerative Biology, a faculty member of the Harvard Stem Cell Institute, and former president of NIBR. He is a consultant for Novartis and MPM Capital, and is on the board of directors of Semma Therapeutics and the scientific advisory board of Tenaya Therapeutics.CRISPR-cas9 is a good example of discovery biology that opened new opportunities in therapeutics. It started as a study of how bacteria resist infection by viruses. Scientists figured out how the tools that bacteria use to cut the DNA of an invading virus could be used to edit the human genome, and possibly to target genetic diseases directly.The origins of CRISPR-Cas9 were not utilitarian, but those discoveries have the potential to open a new field of genomic medicine. Blood pressure medicines would never have been created without the discovery of the role of renin (a renal extract) in regulating blood pressure in 1898. Blood pressure medication is another example of how fundamental discoveries can lead to transformative medicines.People who suffer from high blood pressure often take drugs that act by blocking the angiotensin-converting enzyme. Those medicines would never have been created without the discovery of the role of renin (a renal extract) in regulating blood pressure in 1898, or without the discovery of angiotensin in 1939, or without the solid understanding of how the enzyme works, shown in 1956.This work was not tied earlier to making pills for hypertension, mainly because hypertension was generally believed to be harmless until the 1950s, when studies showed its relationship to heart disease. Before then, the control of blood pressure was itself a fundamental science, beginning with Stephen Hales’ measurement  of blood pressure in a horse in 1733.The discovery of ACE inhibitors really reflects the convergence of two fields of fundamental, curiosity-driven discovery.Yet some observers believe that projects that can demonstrate up front that they could produce something useful should take priority over projects that explore fundamental questions. Would there be many more medicines if academics focused more on programs with practical outcomes? How would that shift affect people in the future?To find answers, Fishman and his colleagues investigated the many scientific and historical paths that have led to new drugs. The study they produced is a contemporary look at the evidence linking basic research to new medicines.The authors used a list of the 28 drugs defined by other scientists as the “most transformative” medicines in the United States between 1985 and 2009. The group examined:Whether the drug’s discovery began with an observation about the roots of disease;Whether the biologist believed that it would be relevant to making a new medicine; andHow long it took to realize that.To mitigate bias, the researchers repeatedly corroborated the assignment with outside experts.They found that eight out of 10 of the medicines on their list led back to a fundamental discovery — or series of discoveries — without a clear path to a new drug.The average time from discovery to new drug approval was 30 years, the majority of which was usually spent in academia, before pharmaceutical or biotechnology companies started the relevant drug development programs.Fishman concluded, “We cannot predict which fundamental discovery will lead to a new drug. But I would say, from this work and my experiences both as a drug discoverer and a fundamental scientist, that the foundation for the next wave of great drugs is being set today by scientists driven by curiosity about the workings of nature.”What industry and academic leaders sayLeaders in biomedicine from industry, business, and academia warmly welcome this new body of evidence, as it supports the case for funding curiosity-driven, non-directed, fundamental research into the workings of life.“This perspective on drug discovery reminds all of us that while many in both industry and academia have been advocating for a more rational approach to R&D, the scientific substrate we depend on results from a less than orderly process. The impact of basic research and sound science is often unpredictable and underestimated. With several telling examples, the authors illustrate how they can have a ripple effect through our field.”– Jean-François Formela, M.D., Partner, Atlas Venture“The paper presents a compelling argument for investing in fundamental, curiosity-driven science. If it often takes decades to recognize when a new discovery should prompt a search for targeted therapeutics, we should continue to incentivize academic scientists to follow their nose and not their wallets.”– George Daley, M.D., Ph.D., Dean of the Faculty of Medicine, Caroline Shields Walker Professor of Medicine, and Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School“There is a famous story of a drunk looking for his lost keys under a streetlight because the light is better there. As Mark reminds us, if we only look for cures where the light has already shone, we will make few if any new discoveries. Basic research shines a light into the dark corners of our understanding, and by that light we can find wonderful new things.”— Dr Laurie Glimcher, M.D., President and CEO of the Dana-Farber Cancer Institute and Richard and Susan Smith Professor of Medicine at Harvard Medical School“The importance of fundamental discovery to advances in medicine has long been a central tenet of academic medicine, and it is wonderful to see that tenet supported by this historical analysis. For those of us committed to supporting this pipeline, it is a critical reminder that young scientists must be supported to pursue out-of-the-box questions and even new fields. In the end, that is one of the key social goods that a research university provides to future generations.”— Katrina Armstrong, M.D., M.S.C.E., Physician-in-Chief, Department of Medicine, Massachusetts General Hospital“Human genetics is powering important advances in translational medicine, opening new doors to treatments for both common and rare diseases at an increasingly rapid pace. Yet, these discoveries still require fundamental, basic scientific understanding into the drug targets’ mechanism of action. In this way, the potential of the science can be unlocked through a combination of curiosity, agility, and cross-functional collaboration to pursue novel therapeutic modalities like gene and cellular therapies, living biologics, and devices. This paper illustrates the value of following the science with an emphasis on practical outcomes and is highly relevant in today’s competitive biopharmaceutical environment, where much of the low-hanging fruit has already been harvested.”– Andy Plump, M.D., Ph.D., Chief Medical and Scientific Officer, Takeda Pharmaceutical Co.“Medicine depends on scientists asking questions, collectively and over generations, about how nature works. The evidence provided by Fishman and colleagues supports an already strong argument for continued and expanded funding of our nation’s primary source of fundamental science: the NIH and the NSF.”– Douglas Melton, Ph.D., Xander University Professor at Harvard, Investigator of the Howard Hughes Medical Institute, and co-director of the Harvard Stem Cell Institute“Just as we cannot translate a language we do not understand, translational medicine cannot exist without fundamental insights to be converted into effective therapies. In their excellent review, Fishman and his colleagues bring the factual evidence needed to enrich the current debate about the optimal use of public funding of biomedical research. The product of public research funding should be primarily fundamental knowledge. The product of industrial R&D should be primarily transformative products based on this knowledge.”— Elias Zerhouni, M.D., President Global R&D Sanofi, former Director of the National Institutes of Health, 2002-2008“Fundamental research is the driver of scientific knowledge. This paper demonstrates that fundamental research led to most of the transformative medicines approved by the FDA between 1985 and 2009. Because many genes and genetic pathways are evolutionarily conserved, discoveries made from studies of organisms that are highly tractable experimentally, such as yeasts, worms, and flies, have often led to and been integrated with findings from studies of more complex organisms to reveal the bases of human disease and identify novel therapeutic targets.”– H. Robert Horvitz, Nobel Laureate; David H. Koch Professor, Member of the McGovern Institute for Brain Research and of the David H. Koch Institute for Integrative Cancer Research, and Howard Hughes Medical Institute Investigator at Massachusetts Institute of Technology“This meticulous and important study of the origin of today’s most successful drugs finds convincingly that the path to discovery lies through untargeted fundamental research. The authors’ clear analysis is an effective counter to today’s restless investors, academic leaders, and philanthropists, whose impatience with academic discovery has itself become an impediment to the conquest of disease.”— Marc Kirschner, John Franklin Enders University Professor, Department of Systems Biology, Harvard Medical School“Some ask if there is a Return on Investment (ROI) in basic biomedical research. With transformative therapies as the ‘R,’ this work traces the path back to the starting ‘I,’ and repeatedly turns up untargeted academic discoveries — not infrequently, two or more that are unrelated to each other. Conclusion? A nation that wants the ‘R’ to keep coming must maintain, or better, step up the ‘I’: that is, funding for curiosity-driven, basic research.”— Keith Yamamoto, UCSF molecular biologist and Vice Chancellor, Science Policy and Strategylast_img read more

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Dames at Sea Sets Broadway Closing Date

first_img Lesli Margherita Dames at Sea Show Closed This production ended its run on Jan. 3, 2016 After struggling with low grosses for some time, Dames at Sea is set to end its Broadway voyage on January 3, 2016. At time of closing, the musical, starring Main Stem fave Lesli Margherita and more, will have played 32 previews and 85 regular performances. Dames at Sea officially opened on October 22 at the Helen Hayes Theatre.Directed by Randy Skinner, Dames at Sea tells the story of Ruby, who steps off a bus from Utah and into her first Broadway show. But hours before the opening night curtain is set to rise, the cast learns that their theater is being demolished. With the help of some adoring sailors, Ruby and the cast set a plan in motion to perform the show in a naval battleship.The cast also includes Mara Davi, Danny Gardner, Eloise Kropp, Cary Tedder and John Bolton.The musical, which features music by Jim Wise and a book and lyrics by George Haimsohn and Robin Miller, first opened at the Bouwerie Lane Theatre in 1968 in a production starring Bernadette Peters, then transferred to the Theater de Lys (now the Lucille Lortel Theatre) in 1969, where it played for 575 performances. This production marked Dames at Sea’s Broadway premiere. A national tour is planned to begin in the fall of 2017.Broadway.com customers with tickets to canceled performances will be contacted with information on refunds or exchanges. Related Shows Star Files View Commentslast_img read more

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Soybean rust in Georgia

first_imgBy Brad HaireUniversity of GeorgiaUniversity of Georgia scientists learned recently that Asiatic soybean rust, a deadly tropical soybean disease, can survive Georgia’s winter weather. This raises concerns that it could spread earlier and stronger this year.Other than soybeans, the disease thrives on Florida beggarweed and kudzu, an Asian vine that’s notorious in the South.It was found growing on live kudzu in Grady County Jan. 30 and Thomas County Feb. 10, said Bob Kemerait, a UGA Cooperative Extension plant pathologist. It has been confirmed on kudzu in two counties in south Alabama, too, and 11 counties in Florida so far this year, he said.Kudzu, Florida beggarweed and any soybeans left from the previous year’s harvest are usually killed by freezing temperatures each year in Georgia. But nothing is guaranteed.”These sites answer the question, can Asiatic soybean rust overwinter in Georgia?” Kemerait said. “The answer is yes.”The infected kudzu in Grady County was found protected from the cold weather by a building in downtown Cairo, Ga. The infected kudzu in Thomas County was protected by a concrete culvert.The living kudzu from the two sites was taken to the UGA Plant Disease Diagnostics Laboratory in Tifton, Ga., Feb. 17 to be studied. It will be destroyed, Kemerait said.The disease is in Georgia now, he said. There are probably other south Georgia sites similar to those in Grady and Thomas counties where the disease and kudzu are protected from freezing weather.Georgia farmers who choose to plant soybeans this year need to budget an extra $20 to $30 per acre to protect the crop with fungicides. Before the threat of the disease, Georgia farmers rarely needed to spray fungicides on soybeans.Because of the threat the disease poses to Georgia and the rest of the country, Kemerait and UGA Extension agents in south Georgia monitored the state for it this winter. A U.S. Department of Agriculture grant has helped in the search.Asiatic soybean rust first appeared in the United States in November 2004 on the Gulf Coast. Scientists believe it blew in on tropical storms that skirted South America, where the disease has already cost soybean farmers billions of dollars in damage.Kemerait and other scientists with the UGA College of Agricultural and Environmental Sciences will conduct fungicide spray trials this year to determine the optimal time to spray for the disease and the best fungicides to use.Georgia is not considered a major soybean-growing state. Georgia farmers grew about 170,000 acres in 2005. The crop is worth $30 million to $40 million annually.Asiatic soybean rust is here to stay, Kemerait said.When it first shows up and how fast it travels will determine how much of a threat it will be for the Midwest, where most U.S. soybeans are grown. The U.S. is the world’s leading soybean producer. The crop is worth about $18 billion annually.last_img read more

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This week: Action near on tax reform, government spending

first_img continue reading » The House and Senate this week are expected to take up the final tax reform bill, which, to NAFCU’s urging, keeps the credit union tax exemption intact. Both chambers hope to have the bill passed and on the president’s desk for his signature before Christmas.NAFCU President and CEO Dan Berger and other members of NAFCU’s legislative affairs team have been actively engaged on Capitol Hill and with the White House to ensure the credit union tax exemption is left alone in this tax bill. In August, the association and several member credit union representatives met with Treasury Secretary Steven Mnuchin to discuss tax reform efforts, and Berger was invited on FOX Business to explain the importance of the exemption. The association has also held numerous meetings with senators, representatives and administration officials throughout the year.Last month, NAFCU launched a grassroots effort calling on member credit unions to defend the industry’s tax-exempt status at the local level. An independent tax study released by NAFCU earlier this year found the credit union tax exemption benefits $16 billion to the U.S. economy each year. (Read more on the tax bill here.) 8SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblrlast_img read more

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Shkodran Mustafi sarcastically apologises to Arsenal fan for keeping two clean sheets

first_img Unai Emery on Arsenal’s 5-0 win against Nottingham ForestTo view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Play VideoLoaded: 0%0:00Progress: 0%PlayMuteCurrent Time 0:00/Duration Time 10:34FullscreenUnai Emery on Arsenal’s 5-0 win against Nottingham Foresthttps://metro.co.uk/video/unai-emery-arsenals-5-0-win-against-nottingham-forest-2013038/This is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.MORE: Ole Gunnar Solskjaer provides update on Marcus Rashford injury Earlier this month, Mustafi claimed Emery has promised him he will be ‘treated like any other player’ despite being told otherwise in the summer.‘My dad talked to the club. I am a player of Arsenal and have another two years of contract,’ he said.‘I was never the one who starts a war when something does not work out.‘If something turns out, I’m open to taking the next step. If not, then I will continue my football.More: FootballBruno Fernandes responds to Man Utd bust-up rumours with Ole Gunnar SolskjaerNew Manchester United signing Facundo Pellistri responds to Edinson Cavani praiseArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira moves‘The coach told me that he sees me the same way as any player in the team. That’s why I played today.‘I do not want to say that this is not an issue. I have a wife and two children and that has to be sanctioned.‘If at some point a club from Germany has interest and it fits, I’m open for it.’ Shkodran Mustafi sarcastically apologises to Arsenal fan for keeping two clean sheets Shkodran Mustafi has helped Arsenal keep clean sheets in his last two matches (Picture: Getty)Arsenal defender Shkodran Mustafi has bizarrely apologised to an Arsenal fan on Twitter after helping the side keep two clean sheets in his last two matches.Mustafi was deemed surplus to requirements by Arsenal this summer after a calamitous three-year spell in north London, but the 27-year-old refused to leave amid strong interest from Serie A giants Juventus and Roma.Though the Germany international is yet to make a single appearance in the Premier League this season, he has impressed in Arsenal’s cup competitions.Mustafi played every minute as Arsenal beat Eintracht Frankfurt 3-0 in the Europa League before Unai Emery handed him another start at home to Nottingham Forest on Tuesday night.AdvertisementAdvertisementADVERTISEMENTMore: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityHe was relatively untested alongside the returning Rob Holding in central defence as the Gunners put five goals past Forest without conceding to reach the fourth round of the Carabao Cup.Clearly high on confidence after his recent performances, Mustafi was quick to remind fans of his worth as he directly responded to Arsenal supporter @Adewuyi_shola on Twitter.‘I hate to say this but Shkodran Mustafi has played 2 games and kept 2 clean sheet,’ @Adewuyi_shola said.Mustafi replied ‘Sorry for keeping the 2 clean sheets’ with an emoji suggesting he was less than impressed with the initial tweet.Sorry for keeping the 2 clean sheets 😑— Shkodran Mustafi (@MustafiOfficial) September 25, 2019 Metro Sport ReporterWednesday 25 Sep 2019 9:29 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link2.5kSharescenter_img Comment Advertisement Advertisementlast_img read more

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Good for Mike Pence wanting to protect his marriage

first_imgNational Review 30 March 2017Family First Comment: The media and the left are in an uproar because the Vice President made a decision years ago never to place himself in a compromising situation or place of temptation in order to protect his marriage. “If you read the Post’s story in full, you’ll see that Mike Pence believes that, in Karen, he has a great thing going. For knowing himself well enough to avoid screwing that good thing up, he should be praised by the culture, not mocked and maligned. There’s a decency at play there. There’s a humility, too. Good for the vice-president. He’s made his vows, and he’s sure as hell gonna keep ‘em.”Good for him!#protectmarriagewww.protectmarriage.org.nzTwo days ago, the Washington Post ran a fascinating profile on Mr. and Mrs Mike Pence, once sentence from which has inspired both outrage and mockery:In 2002, Mike Pence told the Hill that he never eats alone with a woman other than his wife and that he won’t attend events featuring alcohol without her by his side, either. If themore pointed among the reactions are to be believed, this rule suggests that Pence is a religious weirdo, an enemy of women, a reactionary, or a closet pervert — or perhaps all of the above. Were I to sum up the responses in a single word, that word would be “yuck.”And I can’t for the life of me figure out why. For a start, I cannot imagine being critical of or caustic toward the private decisions that any couple makes in order to strengthen their marriage. If there is any over-zealotry at play here, it is in support of the Pences’ most sacred promises to each other. Have we really reached the point at which that’s abominable?Moreover, I suspect that we are really arguing over degrees, not absolutes. Among the arguments that I’ve seen leveled against Pence are that he “doesn’t trust himself”; that he “doesn’t trust women”; that he must be some sort of sex-addict; that he sees all females as “temptresses” or “sirens”; and that he erroneously regards himself as an “adonis.” “Why,” some have inquired, “does Pence seem to believe that having dinner with a woman will lead inexorably to sex?” None of these critiques makes sense to me. Suppose that instead of saying that he “never eats alone with a woman other than his wife,” Pence had said that he never lets a woman who is not his wife into his hotel rooms. Would that imply that he thinks he’s irresistible? Or that he can’t control himself? Or that he thinks that women are innately nymphomaniacal? Or, alternatively, would it suggest that he wants to avoid giving off the wrong impression – either to other women or to the press — and that he is aware of human nature and the way in which temptation works? I’d argue that the latter is the case, and that by avoiding one-on-one dinners and eschewing drinking when alone, he is merely drawing the line a little closer than would others (and would I).READ MORE: http://www.nationalreview.com/corner/446282/mike-pence-wants-protect-his-marriage-good-himKeep up with family issues in NZ. Receive our weekly emails direct to your Inbox.last_img read more

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Sex and coffee ‘trigger stroke’

first_img 22 Views   no discussions Sharing is caring! Share Share Coffee linked to one in 10 burst blood vessels in the brain.Coffee, sex and blowing your nose could increase the risk of a type of stroke, say researchers in the Netherlands.The study on 250 patients identified eight risk factors linked to bleeding on the brain.They all increase blood pressure which could result in blood vessels bursting, according to research published in the journal Stroke.The Stroke Association said more research was needed to see if the triggers caused the rupture.More than 150,000 people in the UK have a stroke each year with nearly 29,000 due to bleeding on the brain.Bleeding can happen when a weakened blood vessel, known as a brain aneurysm, bursts. This can result in brain damage or death.The researchers at the University Medical Center in Utrecht looked at 250 patients for three years to identify what triggers ruptures.Caffeine dangerThey found that coffee was responsible for more than one in 10 burst brain aneurysms.While people drinking coffee had only a 1.7 times greater risk, it is more common than other risk factors. Being startled increased the risk by more than 23 times, but was responsible for just 2.7% of cases.Dr Monique Vlak, a neurologist and the study’s lead author, said: “All of the triggers induce a sudden and short increase in blood pressure, which seems a possible common cause for aneurysmal rupture.”Lower riskThe authors said one in 50 people has a brain aneurysm, but only a few rupture.Dr Vlak advised that: “Reducing caffeine consumption or treating constipated patients with unruptured intracranial (brain) aneurysms with laxatives may lower the risk of subarachnoid haemorrhage.”The study only looked at the triggers for the burst. High blood pressure weakens blood vessels in the first place and can be caused by being overweight, smoking and a lack of exercise.Dr Sharlin Ahmed, Research Liaison Officer at The Stroke Association said: “A sudden surge in high blood pressure can increase the likelihood of an aneurysm rupturing. However, it’s very difficult to determine whether the triggers identified in this study are definitely related to the onset of a stroke as they could simply be put down to coincidence.“A lot more research needs to be carried out to assess whether each of the identified triggers could directly cause an aneurysm to rupture.”By James Gallagher Health reporter,BBC Newscenter_img Share HealthLifestyle Sex and coffee ‘trigger stroke’ by: – May 6, 2011 Tweetlast_img read more

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Another Haitian migrant vessel runs aground in Bahamas

first_img Share Share Sharing is caring! NewsRegional Another Haitian migrant vessel runs aground in Bahamas by: – November 8, 2011 Tweetcenter_img Share Director of Immigration. Image via: perfectpeople.netNASSAU, Bahamas — A sloop carrying more than 100 Haitian migrants ran aground just south of Harbour Island in The Bahamas on Saturday night, Director of Immigration Jack Thompson told The Nassau Guardian on Sunday.Thompson said the police received reports about the sloop around 7 p.m., and explained that the response from police and immigration officers was immediate.“The 101 men, women and children on board the 60-foot wooden sloop were apprehended and are being processed at this time,” said Thompson.Thompson could not confirm whether or not anyone may have jumped off the vessel in an attempt to swim to land and evade police.“I don’t know if anyone jumped off the vessel while the voyage was in progress. When we speak with these nationals, we get many different stories,” he said.However, he noted that the Department of Immigration intends to remain on the alert.“With our law enforcement partners, the police and defence force, we’re going to be very vigilant with respect to our borders,” he said.He said the group will be tested for cholera before they are repatriated.“Medical officials will follow proper protocol as it relates to cholera,” he said.Since the cholera outbreak in Haiti last year, the Department of Immigration has vigilantly screened all immigrants, according to Thompson. According to the Centers for Disease Control (CDC), an epidemic cholera strain has been confirmed in Haiti. Cholera is a potentially fatal bacterial infection.Thompson said this latest apprehension comes just days after immigration officers conducted an operation which resulted in the apprehension of 44 people.Thompson said the Haitian nationals could not prove to officers that they were in the country legally.The 23 men, 17 women and four children were transported to New Providence for further processing.“This was a joint operation between defence force and immigration officers. We targeted Harbour Island based on our intelligence and complaints from residents,” he said. By Karissma RobinsonNassau Guardian Staff Reporter 7 Views   no discussionslast_img read more

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Video: Napoli’s shot-stopper dribbles Messi during UCL clash as fans react

first_img Loading… But just before they took the lead, Ospina received the ball in his own box and managed to evade a pressing Messi who slid to the turf in the San Paulo Stadium. Check out the clip below. Twitter reacted to the former Arsenal keeper managing to give the 32-year-old a taste of his own medicine. FacebookTwitterWhatsAppEmail分享 Gennaro Gattuso’s side were big underdogs heading into the game and are missing key players such as Kalidou Koulibaly.But the Serie A side took the lead through Mertens’ beautiful curling effort which took him level with Marek Hamsik as ‘Gli Azzurri’s’ all-time top goalscorer.center_img Messi has been ass so far, his best move was that ankle breaker Ospina pulled on him…— 824 (@ViniJrMadrid7) February 25, 2020 Napoli goalkeeper David Ospina managed to send Lionel Messi tumbling to the ground with a body feint – before Dries Mertens put the Italians ahead moments later.The Italian side are hosting Barcelona in the first leg of their Champions League round of 16 tie and took a shock lead in the first half. Read Also: Ronaldo’s son marks Instagram debut with 979,000 followersBarcelona looked toothless going forward and failed to register a shot on target.However, Antoine Griezmann managed to level for Quique Setien’s side just before the hour mark. Promoted ContentBest Car Manufacturers In The WorldCouples Who Celebrated Their Union In A Unique, Unforgettable WayWhat Is A Black Hole And Is It Dangerous For Us All?Best & Worst Celebrity Endorsed Games Ever Made8 Things That Will Happen If An Asteroid Hits Earth5 Of The World’s Most Unique Theme ParksHere Are The Top 10 Tiniest Mobile Phones On The Planet!This Guy Photoshopped Himself Into Celeb Pics And It’s Hysterical10 Risky Jobs Some Women DoTop 10 Most Romantic Nations In The WorldA Hurricane Can Be As Powerful As 10 Atomic BombsIs This 1921 Cartoon The First Ever Meme?last_img read more

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