Collaboration aims to discover new immuno-oncology targets

first_imgHarvard, Merck to collaborate on research led by Harvard immunologist Arlene Sharpe, seeking to identify new pathways for the treatment of cancerHarvard University and Merck are launching a collaboration that will provide significant research funding for up to four years to support immuno-oncology research led by Arlene Sharpe, M.D., Ph.D., at Harvard Medical School (HMS). Sharpe, the George Fabyan Professor of Comparative Pathology and chair of the HMS Department of Immunology, will collaborate with researchers at Merck on a major project aiming to discover novel aspects of the immune system that may be targeted in future treatments for cancer.“This collaborative project aims to discover and validate novel regulators of immune responses,” said Sharpe. “Immunotherapies such as checkpoint inhibitors have revolutionized the treatment of cancer, but my lab is deeply interested in understanding why some patients do not respond or develop resistance to those interventions. My hope is that by defining mechanisms that inhibit immune responses to tumors, we will identify very important druggable targets and new approaches to improve cancer immunotherapy.”The funding will support the work of scientists in the lab of Sharpe, who is a renowned leader in the field of tumor immunology. She is a member of the National Academy of Sciences and the National Academy of Medicine, and the recipient of numerous awards including the Warren Alpert Foundation Prize in 2017 for her contributions to the discovery of the PD-1 pathway.“Crucial insights into patient responses and outcomes may be gained through the study of fundamental biological mechanisms,” said Isaac Kohlberg, Harvard’s chief technology development officer and senior associate provost. “The complexity and promise of immuno-oncology presents a prime opportunity for Harvard’s top scientists to advance discovery through an academic-industry collaboration. Through this project, the Sharpe Lab is setting its sight on innovations that may contribute to dramatic improvements in patient care.”Under the agreement spearheaded by Harvard’s Office of Technology Development, Merck will have the option to negotiate an exclusive license to innovations arising from the research collaboration to develop these discoveries toward potential treatments for patients.“Collaboration with leading scientific groups is an integral part of Merck’s discovery strategy,” said Nick Haining, vice president for oncology discovery at Merck Research Laboratories. “We look forward to working with Sharpe’s team to investigate new ways to harness the immune system for therapeutic advances.” Read Full Storylast_img read more

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Weekend Poll Top Three: Fans Want Laura Osnes in The Music Man!

first_img 2. Sierra Boggess—13% She’s a little busy starring on Broadway right now in The Phantom of the Opera, but maybe she’ll leave the Opera Populaire for the River City library. With the Royal Albert Hall version of Phantom, Boggess already has one filmed production of a musical under her belt. The next move, clearly, is to take it a step further and do it live for millions of people across the country. It’s about time that this Broadway fave gets the national attention that she deserves; no doubt her beautiful voice and comedic chops would win them over! Sierra Boggess Laura Benanti 1. Laura Osnes—33% Back in 2012, Ms. Osnes told us, “Marian Paroo is actually the next [role] on my list.” We here at Broadway.com are all about making casting dreams come true (ask Norm Lewis). It’ll be a bit of a venture from her princess days in Cinderella, but we have no doubt that she would sound beautiful singing “Till There Was You,” which just so happens to be one of her audition songs. We can’t help but think that her victory in this poll had something to do with her Twitter campaigning with Cinderella co-star and one of Broadway.com’s picks to play Harold Hill, Santino Fontana. Laura Osnes Star Files 3. Laura Benanti—11% We already know she can handle the stress of a live production after her performance as Baroness Elsa in last year’s The Sound of Music (who else could trend on Twitter while playing “the other woman?”). Perhaps it’s time for the Broadway and NBC darling to play a leading lady in a live broadcast—especially because there aren’t really any good roles for her in Peter Pan. If she doesn’t do The Music Man, we’ll start a campaign for My Fair Lady in 2016. We’ve got your back, Benanti. View Comments Oh, the Wells Fargo Wagon is a-comin’ to NBC, in a live broadcast of The Music Man! As soon as we heard the news, we started dream casting the role of the smooth-talking con man Harold Hill—from stage favorites to screen stars, so we figured it was only fair that fans got to pick who they think should play Marian “The Librarian” Paroo. You wished they may and you wished they might, and here’s what you had to say!last_img read more

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VEDA accepting applications for new agricultural stimulus financing

first_imgFarmers may apply immediately for the new agricultural stimulus financing available through VEDA s farm lending program, the Vermont Agricultural Credit Corporation (VACC). VACC has up to $6 million in low-interest financing available, made possible by $1 million in federal economic stimulus funds from Vermont s share of the American Recovery and Reinvestment Act.The new loan funding is available to help farmers with this season s operational costs feed, seed, fertilizer or other needs or, to refinance prior years operating costs. The stimulus financing has a variable rate, now at 2%. The term for the financing is generally two years (although terms may be longer under certain circumstances), and the maximum loan amount is $100,000.Detailed information about the program is available on VEDA s website at www.veda.org(link is external). Applications may either be (1) filled out on-line and emailed to VEDA at applications@veda.org(link sends e-mail); or, (2) downloaded from VEDA s website, filled out in print form, and mailed to VACC Farm Operating Loan Program, Vermont Agricultural Credit Corporation, 58 East State Street, Montpelier, Vermont 05602.To learn more, Vermont farmers in need of financing are encouraged to speak with one of VACC s experienced farm lenders by calling, toll-free, 1-866-828-FARM (3276).Established in 1999, VACC is a nonprofit corporation that provides credit to farmers and agricultural facilities whose financing needs are not being fully met by conventional agricultural credit sources. VACC offers financing to strengthen or modernize existing farm operations, encourage diversification, support beginning farmers and encourage marketing and processing of Vermont agricultural products.Source: VEDAlast_img read more

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Avian flu reported in China, Thailand, Vietnam

first_imgNov 4, 2005 (CIDRAP News) – About 9,000 chickens have died and close to 370,000 have been culled in China in the largest of several outbreaks of H5N1 avian influenza reported this week in Asia.Several small avian flu outbreaks have been reported in Thailand and Vietnam, while Japan reported another H5 outbreak in poultry. In addition, an H5 virus was found in some healthy wild ducks in British Columbia, but authorities were confident it was not an H5N1 strain.In a report to the World Organization for Animal Health (OIE) yesterday, Chinese authorities said 8,940 chickens, plus 20 magpies and other wild birds, had died of H5N1 infection in the northeastern province of Liaoning, which borders North Korea.The outbreak triggered the culling of 369,900 more birds within 3 kilometers of the site and the vaccination of another 13.9 million, the report says. An Agence France-Presse (AFP) report said the virus struck farms in six villages.The outbreak was China’s fourth since Oct 19, according to AFP. The other recent outbreaks were in the Inner Mongolia region and in Anhui and Hunan provinces in central China. The country has had no confirmed human cases of H5N1.In Thailand, about 1,700 chickens, broiler ducks, and fighting cocks died in five small outbreaks in two provinces, according to a report authorities filed with the OIE Nov 1. The report listed the disease as highly pathogenic avian flu but did not specify the viral strain. However, Thailand has reported many small H5N1 outbreaks in poultry since a nationwide surveillance program was launched in July.Japanese authorities reported plans to kill 180,000 chickens after finding signs of avian flu on one farm, according to AFP and Associated Press (AP) reports today. The AP said antibodies to H5 viruses had been found in some of the chickens.The reports conflicted on the location. AFP reported that the outbreak was in Ibaraki prefecture near Tokyo, where a number of H5N2 outbreaks have been reported in recent months, but the AP said the outbreak occurred on “a northern farm.”Vietnam has confirmed avian flu outbreaks in three northern villages, according to another AP report today. The story quoted a local official as saying that more than 3,000 poultry died or were destroyed in Bac Giang province.In Canada, about 174 wild ducks out of more than 700 sampled in central British Columbia tested positive for an H5 virus, according to a Nov 1 Canadian Press (CP) report. The report came a day after the announcement that an H5 virus had been found in 28 ducks in Quebec and five in Manitoba.Dr. Ron Lewis, British Columbia’s chief veterinarian, said it was “very unlikely” that the H5 virus found in the ducks was the same as the H5N1 strain in Asia, according to an AFP report.He said the samples all came from young, healthy birds. Fourteen of the samples tested strongly positive, and another 75 were weakly positive, the CP report said. The birds tested were from the Merritt area in south-central British Columbia.The testing was part of a “cross-country” search for viruses carried by wild waterfowl, AFP reported. Lewis said this type of surveillance had not been done before, so authorities didn’t know if the finding should be considered unusual or not, according to the CP.In other news:Croatian authorities reported Nov 2 that a swan that had been shot last week tested positive for H5N1, AFP reported. The swan, which had been tagged in Hungary, was shot in the village of Zdenci, where other swans had tested positive for the virus recently.In Macedonia, tests ruled out avian flu in one of about 1,000 chickens and turkeys that were found dead in mid October, according to AFP. A veterinary official said the tests showed the country is free of avian flu.See also:Chinese report to the OIEThai report to the OIElast_img read more

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New Euro ruling scuppers UK regeneration plans

first_imgTo access this article REGISTER NOWWould you like print copies, app and digital replica access too? SUBSCRIBE for as little as £5 per week. Would you like to read more?Register for free to finish this article.Sign up now for the following benefits:Four FREE articles of your choice per monthBreaking news, comment and analysis from industry experts as it happensChoose from our portfolio of email newsletterslast_img

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‘Trouble shared is…’: South Korea’s Moon conveys support for Jokowi against COVID-19

first_imgSouth Korean President Moon Jae-In has expressed support for President Joko “Jokowi” Widodo in Indonesia’s battle against the coronavirus outbreak.In a statement dated April 21 posted to the official Instagram account of the Embassy of the Republic of Korea in Indonesia (@koremb.idn), South Korean Presidential spokesman Kang Min-seok said that the two Presidents engaged in a 20-minute conversation about the global pandemic and its effect on their countries.”I heard that Indonesia has seen a sharp increase in COVID-19 cases as well as in the number of deaths, and that the Indonesian government has tried its best to curb the outbreak, including declaring [the outbreak] as a national disaster,” Moon said during the conversation, as quoted in the statement published on Wednesday. According to the statement, Jokowi congratulated Moon for South Korea’s success in halting the spread of coronavirus, and that he wished to learn more about Seoul’s experience in managing its outbreak.South Korea has earned praise for its swift response to the COVID-19 pandemic after quickly slowing the rate of infection and deaths, including by rapidly establishing testing facilities across the country and imposing physical distancing measures to limit the spread of the virus.Jokowi also thanked Moon during the call for Seoul’s pledge to donate medical equipment, protective gear and test kits to Jakarta. Moon also expressed his confidence that the Jokowi administration would soon overcome the outbreak through good coordination between the Indonesian government and its citizens.center_img Read also: Emergency aid from South Korea reaches virus-crippled IndonesiaThe South Korean government has pledged a US$500,000 grant-in-kind to Indonesia, which includes medical supplies, COVID-19 test kits and rechargeable power sprayers.The statement said that Jokowi asked Moon to join Indonesia to strengthen international cooperation in addressing the COVID-19 health crisis and the post-pandemic economic crisis.In ending the phone call with Jokowi, Moon quoted the Indonesian proverb “ringan sama dijinjing, berat sama dipikul” (trouble shared is trouble halved) and expressed his hope that the two leaders would intensify communication during this difficult time. (nal)Topics :last_img read more

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Brisbane Gatsby-esque mansion hits the market

first_imgThis property in King Arthur Tce, Tennyson, is for sale.ONE of Brisbane’s most decadent riverfront mansions has hit the market.This property in King Arthur Tce, Tennyson, is for sale.The lavish estate at 121 King Arthur Terrace, Tennyson, is like something out of the pages of F. Scott Fitzgerald’s The Great Gatsby.The decadent dining room in the home.The property encompasses more than 3,500 sqm of riverfront land, with a five-bedroom main residences, a three-bedroom guesthouse and a third building that could be used as a gym or office — all spread across three titles.More from newsParks and wildlife the new lust-haves post coronavirus15 hours agoNoosa’s best beachfront penthouse is about to hit the market15 hours agoThe view from the living and dining area of the home.Features include an eight-person spa with sweeping views, internal lift, a wine cellar, 12-seat cinema, riverside pavilion with its own kitchen and bathroom, private jetty and pontoon, in-ground pool and tennis court.One of the bathrooms in the property at 121 King Arthur Tce, Tennyson.Records show the property was last listed for sale in 2004 for $4.2 million.It’s for sale via tender through Sarah Hackett of Place – Bulimba, with inspections by appointment only.This property at 121 King Arthur Tce, Tennyson, is for sale.last_img read more

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Ban on abortion after 19 weeks (Sth Carolina)

first_imgFox News 18 May 2016Family First Comment: 17th state to introduce this law! NZ needs to be the 18th The South Carolina Legislature passed a bill Tuesday prohibiting abortion after 19 weeks, becoming the 17th state to pass the restrictive ban.The legislation will now head to Gov. Nikki Haley’s desk. The Republican said in March she will almost certainly sign it, but wants to look at the details once it reaches her.Similar laws are in effect in 12 states. They’ve been blocked by court challenges in three others, and the U.S. Supreme Court has yet to rule on the ban’s constitutionality. A South Dakota law signed in March takes effect this summer.In Utah, a related law, also signed in March, requires doctors to provide anesthesia to a fetus at least 20 weeks in the womb.The South Carolina bill is among several fronts abortion rights supporters say make having the procedure tougher. Abortion opponents have also passed laws in other states requiring clinics to get admitting privileges for doctors and banning a procedure commonly used in the second trimester, called the dilation and evacuation method.The sponsor of South Carolina’s bill, Rep. Wendy Nanney, said she’s hopeful the law is a step to eventually “get rid of abortion altogether.”READ MORE: http://www.foxnews.com/politics/2016/05/18/south-carolina-lawmakers-approve-bill-banning-abortion-after-19-weeks.htmllast_img read more

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Chinese football teams rush home again to avoid virus

first_img However, getting back to China is not straightforward because of flight disruptions and strict quarantine rules when coming home. Wuhan Zall were stranded in Frankfurt, Germany on Sunday, according to Chinese media, and their current location was not immediately available. The Beijing News reported that Li Tie’s national team were curtailing their stint in Dubai and had planned to fly back to the Chinese capital from Dubai. Promoted ContentTop 10 Most Romantic Nations In The WorldCouples Who Celebrated Their Union In A Unique, Unforgettable Way6 Extreme Facts About HurricanesBirds Enjoy Living In A Gallery Space Created For ThemWhat Happens To Your Brain When You Play Too Much Video Games?7 Of The Wealthiest Universities In The WorldHere Are The Top 10 Tiniest Mobile Phones On The Planet!7 Ways To Understand Your Girlfriend Better11 Most Immersive Game To Play On Your Table Top2020 Tattoo Trends: Here’s What You’ll See This YearThe Very Last Bitcoin Will Be Mined Around 2140. Read More10 Disney Characters Who Would Make Great Role Models Read Also: Pogba makes coronavirus fund-raising pledge However, their return is also becoming complicated, as Beijing authorities are now sending all international arrivals in the capital to quarantine facilities. After declaring it had “basically” curbed the spread of the disease within the country, China is now worried about an influx of infections from other countries. There have been more than 6,400 confirmed deaths globally from the coronavirus, which emerged in Wuhan in December. Many prominent sports competitions across the globe have been halted. FacebookTwitterWhatsAppEmail分享 Most Chinese Super League (CSL) clubs fled abroad when the deadly coronavirus hit the country but they are now rushing back again as it takes hold elsewhere. Chinese fans held a message of support for Wuhan during a women’s Olympic football qualifier in Sydney The national side is still training in Dubai – where many CSL teams also went in recent weeks – but they too are now making hasty arrangements to get home as soon as possible. Wuhan Zall, from the city at the epicentre of the outbreak, had been training in Spain since late January but left at the weekend because of the worsening situation in Europe, now the focal point of the pandemic. Wuhan will reportedly continue their chaotic pre-season preparations in Shenzhen. Wuhan itself is still in lockdown, despite virus numbers in China reducing. The CSL season was supposed to begin on February 22 but was indefinitely postponed. It could start behind closed doors in May, according to reports. Leo Baptistao, Wuhan’s Brazilian attacker, told Chinese media before departing Spain that the situation “has flipped”. “We are more in danger (here). It now appears… better to leave,” he said. Fabio Cannavaro’s CSL champions Guangzhou Evergrande, who were in Dubai, and runners-up Beijing Guoan are among the clubs that have recently returned to China. Guangzhou R&F, coached by former Arsenal and Barcelona star Giovanni van Bronckhorst, on Monday became the latest club to say they were cutting short their Dubai training camp. Loading… last_img read more

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Man City cruise past 10-man Fulham in FA Cup

first_imgRelatedPosts Gundogan tests positive for coronavirus Solskjaer criticises England over handling of youngster Greenwood Aguero could be out of action until November, Guardiola says Holders Manchester City cruised into the FA Cup fifth round with a 4-0 thrashing of 10-man Fulham at the Etihad on Sunday. Tim Ream’s sixth-minute red card gave the Championship side a mountain to climb after he hauled down Gabriel Jesus inside the box. Ilkay Gundogan converted the resulting penalty before Bernardo Silva’s smart turn and shot quickly doubled City’s advantage. The visitors then held out for nearly an hour but two headers in three minutes from Jesus gave the scoreline a more accurate reflection of the English champions’ dominance. Pep Guardiola’s men have now won 17 domestic cup ties in a row. The Catalan is relying on more cup success for silverware this season after conceding the Premier League title is beyond his side with Liverpool 16 points clear at the top of the table. Guardiola made eight changes to the team that won 1-0 at Sheffield United in midweek, but still named a strong side with both David and Bernardo Silva and Gundogan among those coming into the team. Fulham boss Scott Parker also rotated with his priority securing a return to the Premier League at the first time of asking. Any hope of an upset was quashed within minutes by a rash challenge from Ream. City have had problems from the spot this season with Guardiola even claiming goalkeeper Ederson is his best taker after Jesus’ latest miss at Bramall Lane on Tuesday. However, with the Brazilian on the bench with Claudio Bravo keeping his starting spot in goal for the cups, it was Gundogan who took responsibility to dispatch the spot-kick. A moment of magic from Bernardo then gave the hosts breathing space as the Portuguese international fired into the bottom corner from outside the box. Only a lack of killer instinct prevented City from further running up the score as Raheem Sterling came off the bench to hit the crossbar. Jesus, though, bagged a confidence-boosting double by heading home Joao Cancelo’s cross before nodding in the rebound after Marek Rodak had saved Phil Foden’s initial effort.Tags: EtihadFA CupGabriel JesusIlkay GundoganManchester CityPhil Fodenlast_img read more

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